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Cannabinoid use in progressive inflammatory brain disease (cupid) MRI sub-study.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Shahrukh Mallik, Susan Ball, Catherine Dalton, David Macmanus, Daniel Tozer, David Miller, John Zajicek
Institute of Neurology, UCL; Plymouth University Peninsula Schools of Medicine and Dentistry.
In progressive Multiple Sclerosis (MS), there is no proven therapy for preventing accumulation of irreversible disability. The pathological substrate of irreversible disability in MS is neuroaxonal loss, and brain tissue volume loss on MRI can infer such pathology. There is experimental evidence to suggest that cannabinoids may have a neuroprotective and anti-inflammatory effect, although in a recent UK clinical trial (CUPID), oral cannabinoid did not slow the development of disability in progressive MS compared with placebo.
PMID: 24108959 [PubMed - as supplied by publisher]