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Grey matter and csf amyloid in early non-demented Parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation in Parkinson's disease (icicle-pd) study.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Gordon W Duncan, Alison J Yarnall, Michael J Firbank, Roger A Barker, John T O'Brien, David J Burn
University of Newcastle; University of Cambridge.
Dementia is a frequent and disabling complication of Parkinson's disease (PD). Currently, there are no biomarkers capable of identifiying those at greatest risk of developing Parkinson's disease dementia (PDD). MRI studies using voxel-based morphometry (VBM) report grey matter (GM) loss in PDD and in those with mild cognitive impairment, but, not in early PD. Increasing evidence supports a synergistic role between the accumulation of ?-synuclein and amyloid ? in the pathophysiology of PDD. Lower levels of A?1-40 and A?1-42 in cerebrospinal fluid (CSF) of PD patients have been associated with subsequent cognitive decline. We aimed to determine whether GM volume in early non-demented PD (PD-ND) correlated with CSF levels of A?1-40 and A?1-42.
PMID: 24108928 [PubMed - as supplied by publisher]