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?9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPAR? DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Marie-Louise Zeissler, Jordan Eastwood, C Oliver Hanemann, John Zajicek, Camille Carroll
Plymouth University Peninsula Schools of Medicine and Dentistry.
Cannabinoids such as ?9-tetrahydrocannabinol (?9-THC) are neuroprotective in animal and cell culture models of Parkinson's disease (PD). In a PD cell culture model we recently demonstrated that ?9-THC is neuroprotective through activation of the nuclear receptor peroxisomal proliferator-activated receptor ? (PPAR?). Furthermore, activation by specific agonists rosiglitazone and pioglitazone, has also been found neuroprotective. PPAR? is a nuclear receptor whose activation can lead to the expression of proteins involved in the de novo synthesis of mitochondria. One such protein is the PPAR? co-activator 1 ? (PGC1?) as it co-activates NRF-1 mediated gene expression which is essential for the production of nuclear encoded, mitochondrial proteins. Here we investigate the effect of ?9-THC and pioglitazone on mitochondrial biogenesis.
PMID: 24108924 [PubMed - as supplied by publisher]