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A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers.
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Chem Commun (Camb) 2013 Oct;
Authors: Michael Hernandez, Yang Hu, Jin Ryoun Kim
Department of Chemical and Biomolecular Engineering, Polytechnic Institute of NYU, 6 MetroTech Center, Brooklyn, NY 11201, USA. email@example.com.
We engineered the structural flexibility of an ? synuclein (?S) variant, PG65, together with conformation-sensitive fluorescence to create a molecular probe for rapid, specific and quantitative detection of ?S oligomers, which are the major toxic aggregate forms in Parkinson's disease.
PMID: 24100452 [PubMed - as supplied by publisher]