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Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts.
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Transl Neurodegener 2013 Oct; 2(1):20
Authors: Nady Braidy, Wei-Ping Gai, Ying Hua Xu, Perminder Sachdev, Gilles J Guillemin, Xing-Mai Jiang, J William Ballard, Martin P Horan, Zhi Ming Fang, Beng H Chong, Daniel Kam Chan
The accumulation and aggregation of alpha-synuclein (alpha-syn) in several tissue including the brain is a major pathological hallmark in Parkinson's disease (PD). In this study, we show that alpha-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our findings that brain and peripheral cells exposed to alpha-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of alpha-syn in human cells.
PMID: 24093918 [PubMed - as supplied by publisher]