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?-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal Models.
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Neurodegener Dis 2013 Sep;
Authors: Judith Eschbach, Karin M Danzer
Department of Neurology, University of Ulm, Ulm, Germany.
Parkinson's disease is a common neurodegenerative disease characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of ?-synuclein aggregates found in Lewy bodies throughout the brain. Several ?-synuclein transgenic mouse models have been generated, as well as viral-mediated overexpression of wild-type and mutated ?-synuclein to mimic the disease and to delineate the pathogenic pathway of ?-synuclein-mediated toxicity and neurodegeneration. In this review, we will recapitulate what we have learned about the function of ?-synuclein and ?-synuclein-mediated toxicity through studies of transgenic animal models, inducible animal models and viral-based models. © 2013 S. Karger AG, Basel.
PMID: 24080741 [PubMed - as supplied by publisher]