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0239? Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders0239? Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders.
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Occup Environ Med 2014 Jun; 71 Suppl 1:A32
Authors: Susan Nielsen, Harvey Checkoway, Susan Criswell, Federico Farin, Brad Racette
To assess whether parkinsonism in manganese (Mn)-exposed welders is associated with methylation of NOS2, a methylation-regulated gene that codes for inducible nitric oxide synthase (iNOS). We hypothesised that parkinsonian welders would have lower NOS2 methylation than other welders, consistent with greater iNOS activity and an inflammatory pathogenesis.
PMID: 25018322 [PubMed - as supplied by publisher]