Adjust Text Size:change font sizechange font sizechange font sizechange font sizechange font sizechange font size

Featured Research

Can we predict who is at risk of facing cognitive issues in PD and address them earlier? These are the questions being pursued by Dr. Goldman of the PDF Research Center at Rush University Medical Center.

Learn More

PDF Grant Programs

Are you interested in furthering Parkinson's science? View PDF's open grant programs.

Learn More

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

Mov Disord 2014 Jul;

Authors: Anke A Dijkstra, Pieter Voorn, Henk W Berendse, Henk J Groenewegen, , Annemieke J M Rozemuller, Wilma D J van de Berg

To gain a better understanding of the significance of ?-synuclein pathological conditions during disease progression in Parkinson's disease, we investigated whether 1) nigral neuronal loss in incidental Lewy body disease and Parkinson's disease donors is associated with the local burden ?-synuclein pathological conditions during progression of pathological conditions; 2) the burden and distribution of ?-synuclein pathological conditions are related to clinical measures of disease progression. Post-mortem tissue and medical records of 24 Parkinson's disease patients, 20 incidental Lewy body disease donors, and 12 age-matched controls were obtained from the Netherlands Brain Bank for morphometric analysis. We observed a 20% decrease in nigral neuronal cell density in incidental Lewy body disease compared with controls. Nigral neuronal loss (12%) was already observed before the appearance ?-synuclein aggregates. The progression from Braak ?-synuclein stage 3 to 4 was associated with a significant decline in neuronal cell density (46%). Nigral neuronal loss increased with later Braak ?-synuclein stages but did not vary across consecutive Braak ?-synuclein stages. We observed a negative correlation between neuronal density and local ?-synuclein burden in the substantia nigra of Parkinson's disease patients (??=?-0.54), but no relationship with Hoehn & Yahr stage or disease duration. In conclusion, our findings cast doubt on the pathogenic role of ?-synuclein aggregates in elderly, but do suggest that the severity of neurodegeneration and local burden of ?-synuclein pathological conditions are closely coupled during disease progression in Parkinson's disease. © 2014 International Parkinson and Movement Disorder Society.

PMID: 24996051 [PubMed - as supplied by publisher]

See More

Back to PubMed Articles