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Determination of the biodistribution and dosimetry of (123)I-FP-CIT in male patients with suspected Parkinsonism or Lewy body dementia using planar and combined planar and SPECT/CT imaging.
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Appl Radiat Isot 2013 Sep; 82C:300-307
Authors: Marie Sydoff, Helena Lizana, Sören Mattsson, Michael G Stabin, Sigrid Leide-Svegborn
Medical Radiation Physics, Department of Clinical physiology and Nuclear medicine, Malmö, Lund University, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden. Electronic address: firstname.lastname@example.org.
In this study, (123)I-FP-CIT biodistribution and dosimetry was determined in 10 adult male patients using planar gamma camera imaging alone or in combination with single photon emission computed tomography /X-ray computed tomography (SPECT/CT) imaging. Dosimetric assessment using planar plus SPECT/CT imaging resulted in significantly different estimates of organ-absorbed doses compared to estimates based on planar imaging alone. We conclude that the use of complementary SPECT/CT measurements in biodistribution studies is valuable for determining the organ doses more accurately.
PMID: 24135637 [PubMed - as supplied by publisher]