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Electrical engram: how deep brain stimulation affects memory.
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Trends Cogn Sci 2013 Oct;
Authors: Hweeling Lee, JŁrgen Fell, Nikolai Axmacher
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. Electronic address: firstname.lastname@example.org.
Deep brain stimulation (DBS) is a surgical procedure involving implantation of a pacemaker that sends electric impulses to specific brain regions. DBS has been applied in patients with Parkinson's disease, depression, and obsessive-compulsive disorder (among others), and more recently in patients with Alzheimer's disease to improve memory functions. Current DBS approaches are based on the concept that high-frequency stimulation inhibits or excites specific brain regions. However, because DBS entails the application of repetitive electrical stimuli, it primarily exerts an effect on extracellular field-potential oscillations similar to those recorded with electroencephalography. Here, we suggest a new perspective on how DBS may ameliorate memory dysfunction: it may enhance normal electrophysiological patterns underlying long-term memory processes within the medial temporal lobe.
PMID: 24126128 [PubMed - as supplied by publisher]