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Increase of the plasma ?-synuclein levels in patients with multiple system atrophy.
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Mov Disord 2013 Sep;
Authors: Zhan-Fang Sun, Xiao-Shuang Xiang, Zhao Chen, Li Zhang, Bei-Sha Tang, Kun Xia, Hong Jiang
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Multiple system atrophy, a sporadic neurodegenerative disease, is characterized by the presence of high numbers of glial cytoplasmic inclusions mainly formed by ?-synuclein protein, which is encoded by the SNCA gene. To date, however, few studies have investigated the plasma ?-synuclein levels in patients with multiple system atrophy. We studied plasma ?-synuclein concentrations by using an enzyme-linked immunosorbent assay in 74 patients with multiple system atrophy and 90 healthy controls. The plasma ?-synuclein levels were significantly elevated in patients who had multiple system atrophy compared with the control group (P?=?0.000). In a subgroup of 48 patients who had probable multiple system atrophy, there was a weakly negative correlation between plasma ?-synuclein levels and subscores on Unified Multiple System Atrophy Rating Scale item VI (rs ?=?-0.307; P?=?0.034). Plasma ?-synuclein levels were elevated in patients with multiple system atrophy, and these levels may be decreased with the development of disease. © 2013 International Parkinson and Movement Disorder Society.
PMID: 24115000 [PubMed - as supplied by publisher]